Article
Recognition of tertiary structure in tRNAs by Rh(phen)2phi3+, a new reagent for RNA structure-function mapping.
Biochemistry - 4 Feb 1992
Chow C S, Behlen L S, Uhlenbeck O C, Barton J K
Abstract excerpt
With photoactivation Rh(phen)2phi3+ promotes strand cleavage at sites of tertiary interaction in tRNA. The rhodium complex, which binds double-helical DNA by intercalation in the major groove, yields no cleavage in double-helical regions of the RNA or in unstructured single-stranded regions. Inst...
Topics
- 2,2'-Dipyridyl
- Guanine
- Hydrolysis
- Magnesium Chloride
- Mutation
- Nucleic Acid Conformation
- Organometallic Compounds
- RNA, Fungal
- RNA, Transfer, Asp
- RNA, Transfer, Phe
- Rhodium
- Saccharomyces cerevisiae
- Sodium Chloride
- Structure-Activity Relationship