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Article

Enhanced binding activity of an apolipoprotein E mutant, APO E5, to LDL receptors on human fibroblasts.

Biochemical and biophysical research communications - 30 Apr 1990

Dong L M, Yamamura T, Yamamoto A

Abstract excerpt

We have previously demonstrated an apolipoprotein E (apo E) mutant, apo E5, associated with hyperlipidemia and atherosclerotic vascular diseases. To investigate the possible mechanism of apo E5 involvement in the development of hyperlipidemia, we have isolated the apo E isoprotein and determined its binding activity to LDL (low density lipoprotein) receptors. It was shown that the apo E5 isoprotein was two times...

Topics

Apolipoproteins E
Arteriosclerosis
Dimyristoylphosphatidylcholine
Fibroblasts
Humans
Hyperlipidemias
Isoelectric Focusing
Mutation
Receptors, LDL

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2334412
DOI: 10.1016/0006-291x(90)92336-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2334412-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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