Article
Influence of apoE content on receptor binding of large, bouyant LDL in subjects with different LDL subclass phenotypes.
Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 1998
Barbagallo C M, Levine G A, Blanche P J, Ishida B Y, Krauss R M
Abstract excerpt
We investigated the influence of apolipoprotein (apo) E-containing particles on LDL receptor binding of large, buoyant LDL subfractions (LDL I) from subjects with predominantly large (phenotype A) and small (phenotype B) LDL particles. Direct binding by human fibroblast LDL receptors was tested at 4 degrees C before and after removal of apoE-containing particles by immunoaffinity chromatography. The binding...
Topics
- Adult
- Aged
- Apolipoproteins
- Apolipoproteins E
- Binding, Competitive
- Cell Line
- Fibroblasts
- Humans
- Lipids
- Lipoproteins
- Lipoproteins, LDL
- Male
- Middle Aged
- Phenotype
- Receptors, LDL
- Ultracentrifugation
