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Article

Quantitative analysis of the CD4 T-cell repertoire specific to therapeutic antibodies in healthy donors.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2011

Delluc Stephanie, Ravot Gilles, Maillere Bernard

Abstract excerpt

Therapeutic antibodies are generally partially to fully humanized, yet they can show unwanted immunogenicity and lead to antibody response and adverse effects when administered to humans. As immunogenicity relies on a T-cell-dependent mechanism, we have evaluated in vitro the size of the preexisting CD4 T-cell repertoire specific to therapeutic antibodies in healthy donors. Specific CD4 T cells of individuals...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21368101
DOI: 10.1096/fj.10-173872

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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