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Article

IgE sequences in individuals living in an area of endemic parasitism show little mutational evidence of antigen selection.

Scandinavian journal of immunology - 1 May 2011

Wang Y, Jackson K J L, Chen Z, Gaëta B A, Siba P M, Pomat W, Walpole E, Rimmer J, Sewell W A, Collins A M

Abstract excerpt

Patterns of somatic mutation in IgE genes from allergic individuals have been a focus of study for many years, but IgE sequences have never been reported from parasitized individuals. To study the role of antigen selection in the evolution of the anti-parasite response, we therefore generated 118 IgE sequences from donors living in Papua New Guinea (PNG), an area of endemic parasitism. For comparison, we also...

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Identifiers

PMID: 21284686
DOI: 10.1111/j.1365-3083.2011.02525.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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