IgE sequences in individuals living in an area of endemic parasitism show little mutational evidence of antigen selection.

doi:10.1111/j.1365-3083.2011.02525.x

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Article

IgE sequences in individuals living in an area of endemic parasitism show little mutational evidence of antigen selection.

Scandinavian journal of immunology - 1 May 2011

Wang Y, Jackson K J L, Chen Z, Gaëta B A, Siba P M, Pomat W, Walpole E, Rimmer J, Sewell W A, Collins A M

Abstract excerpt

Patterns of somatic mutation in IgE genes from allergic individuals have been a focus of study for many years, but IgE sequences have never been reported from parasitized individuals. To study the role of antigen selection in the evolution of the anti-parasite response, we therefore generated 118 IgE sequences from donors living in Papua New Guinea (PNG), an area of endemic parasitism. For comparison, we also...

Topics

Adult
Animals
Antigenic Variation
Antigens, Helminth
Base Sequence
Complementarity Determining Regions
Computational Biology
Helminthiasis
Helminths
Humans
Immunoglobulin E
Immunoglobulin G
Middle Aged

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Immunological

Molecular Sequence Data

Mutation

Papua New Guinea

Polymorphism, Single Nucleotide

Source

Open in PubMed

Identifiers

PMID: 21284686
DOI: 10.1111/j.1365-3083.2011.02525.x

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