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Article

Renin cells with defective Gsα/cAMP signaling contribute to renal endothelial damage.

Pflugers Archiv : European journal of physiology - 1 Sept 2019

Steglich Anne, Kessel Friederike, Hickmann Linda, Gerlach Michael, Lachmann Peter, Gembardt Florian, Lesche Mathias, Dahl Andreas, Federlein Anna, Schweda Frank, Hugo Christian P M, Todorov Vladimir T

Abstract excerpt

Synthesis of renin in renal renin-producing cells (RPCs) is controlled via the intracellular messenger cAMP. Interference with cAMP-mediated signaling by inducible knockout of Gs-alpha (Gsα) in RPCs of adult mice resulted in a complex adverse kidney phenotype. Therein, glomerular endothelial damage was most striking. In this study, we investigated whether Gsα knockout leads to a loss of RPCs, which itself may...

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PMID: 31388748
DOI: 10.1007/s00424-019-02298-9

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