Article
Control of cell-fate plasticity and maintenance of multipotency by DAF-16/FoxO in quiescent Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America - 5 Feb 2013
Karp Xantha, Greenwald Iva
Abstract excerpt
The Caenorhabditis elegans vulval precursor cells (VPCs) offer a paradigm for investigating how multipotency of progenitor cells is maintained during periods of quiescence. The VPCs are born in the first larval stage. When hermaphrodites are grown under favorable conditions, the EGF-mediated "ind...
Topics
- Animals
- Animals, Genetically Modified
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- ErbB Receptors
- Female
- Forkhead Transcription Factors
- Gene Expression Regulation, Developmental
- Genes, Helminth
- Larva
- Male
- Membrane Proteins
- Multipotent Stem Cells
- Mutation
- Receptors, Notch
- Signal Transduction
- Transcription Factors
- Vulva