JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration

Abstract excerpt

Age-related macular degeneration (AMD) is the leading cause of registered blindness among the elderly and affects over 30 million people worldwide. It is well established that oxidative stress, inflammation, and apoptosis play critical roles in pathogenesis of AMD. In advanced wet AMD, although, most of the severe vision loss is due to bleeding and exudation of choroidal neovascularization (CNV), and it is well...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
• Share to Ocular Diseases and Behçet’s Syndrome
• Share to Retinal Diseases and Treatments