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SPI1-mediated macrophage polarization aggravates age-related macular degeneration

24 Jun 2024

Abstract excerpt

Objective This study revealed a core regulator and common upstream mechanisms for the multifaceted pathological processes of age-related macular degeneration (AMD) and provided proof-of-concept for this new therapeutic target. Methods Comprehensive gene expression analysis was performed using RNA sequencing of eye cup from old mice as well as laser-induced choroidal neovascularization (CNV) mouse model. Through...

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PMID: 38979414
DOI: 10.3389/fimmu.2024.1421012

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