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Article

Antimicrobial drug resistance affects broad changes in metabolomic phenotype in addition to secondary metabolism.

Proceedings of the National Academy of Sciences of the United States of America - 5 Feb 2013

Derewacz Dagmara K, Goodwin Cody R, McNees C Ruth, McLean John A, Bachmann Brian O

Abstract excerpt

Bacteria develop resistance to many classes of antibiotics vertically, by engendering mutations in genes encoding transcriptional and translational apparatus. These severe adaptations affect global transcription, translation, and the correspondingly affected metabolism. Here, we characterize metabolome scale changes in transcriptional and translational mutants in a genomically characterized Nocardiopsis, a...

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Identifiers

PMID: 23341601
DOI: 10.1073/pnas.1218524110
PMCID: PMC3568320

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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