Article

Discovery of homogentisic acid as a precursor in trimethoprim metabolism and natural product biosynthesis

2022-09-25

Abstract excerpt

Opportunistic infections by Burkholderia cenocepacia are life threatening for patients suffering from cystic fibrosis and chronic granulomatous disease. These infections are often associated with variable clinical outcomes, prompting an interest into molecular investigations of phenotypes associated with disease severity. The production of the pyomelanin pigment is one such phenotype, which was recently linked to...

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Literature Corpus work: 1652a7bf-3780-5d76-bdde-a7211c46c43a
DOI: 10.1101/2022.09.22.509022

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