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Article

Direct Evidence for Epithelial-Mesenchymal Transitions in Breast Cancer

1 Feb 2008

Abstract excerpt

We developed stromal- and epithelial-specific cre-transgenic mice to directly visualize epithelial-mesenchymal transition (EMT) during cancer progression in vivo. Using three different oncogene-driven mouse mammary tumor models and cell-fate mapping strategies, we show in vivo evidence for the existence of EMT in breast cancer and show that myc can specifically elicit this process. Hierarchical cluster analysis...

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Identifiers

PMID: 18245497
DOI: 10.1158/0008-5472.can-07-2148

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