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Article

Epithelial to mesenchymal transition in human breast epithelial cells transformed by 17beta-estradiol.

Cancer research - 1 Dec 2007

Huang Yong, Fernandez Sandra V, Goodwin Shirlean, Russo Patricia A, Russo Irma H, Sutter Thomas R, Russo Jose

Abstract excerpt

The estrogen dependence of breast cancer has long been recognized; however, the role of 17beta-estradiol (E(2)) in cancer initiation was not known until we showed that it induces complete neoplastic transformation of the human breast epithelial cells MCF-10F. E(2) treatment of MCF-10F cells progressively induced high colony efficiency and loss of ductulogenesis in early transformed (trMCF) cells and invasiveness...

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Source

Identifiers

PMID: 18056439
DOI: 10.1158/0008-5472.CAN-07-1371

Genes

HRAS
SNAI2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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