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Article

Adaptive evolution of GPR39 in diverse directions in vertebrates.

General and comparative endocrinology - 1 Dec 2020

Zhang Lina, Song Jingjing, Zang Zhuqing, Tang Huihao, Li Wei, Lai Shanshan, Deng Cheng

Abstract excerpt

G protein-coupled receptors (GPCRs) play an important role in physiology and disease and represent productive drug targets. Orphan GPCRs, which have unknown endogenous ligands, are considered drug targets and consequently have attracted great interest in identifying their endogenous cognate ligands for deorphanization. However, additional studies have shown that GPCRs, including many orphan GPCRs, can...

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PMID: 32916170
DOI: 10.1016/j.ygcen.2020.113610

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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