Article
Two naturally occurring mutations of human GPR103 define distinct G protein selection bias.
Biochimica et biophysica acta. Molecular cell research - 1 Jun 2021
Ma Qiang, Cao Zheng, Li Huanzheng, Wang Weiwei, Tian Yanan, Yan Lili, Liao Yuan, Chen Xiangnan, Chen Yu, Shi Ying, Tang Shaohua, Zhou Naiming
Abstract excerpt
The neuropeptide 26RFa plays important roles in the regulation of many physiological functions. 26RFa has been recognized as an endogenous ligand for receptor GPR103. In the present study, we demonstrate that GPR103 dually couples to Gαq and Gαi/o proteins. However, two naturally occurring missense mutations were identified from a young male patient. In the first, Y68H, induction of Ca2+ mobilization was noted...
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