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Article

Splicing factor mutations clearance and outcomes in clonal myeloid neoplasms: a referral center experience.

Annals of hematology - 6 Jun 2026

Tanariyakul Manasawee, Mott Sarah, Daniels Bethany, Yaganti Avani, Wannaphut Chalothorn, Hornberg Sarah, Dhakal Prajwal, Sutamtewagul Grerk, Poonsombudlert Kittika

Abstract excerpt

Splicing factor (SF) mutations (SF3B1, SRSF2, U2AF1, and ZRSR2) are implicated in the pathogenesis of myelodysplastic syndrome (MDS), chronic myelomonocytic leukemia (CMML), and acute myeloid leukemia (AML). However, additional cytogenetic aberrations or driver mutations are typically required for the development of AML, raising questions about the utility of SF mutation persistence as a marker of measurable...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

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Source

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Identifiers

PMID: 42249961
DOI: 10.1007/s00277-026-07111-z
PMCID: PMC13461927

Genes

SF3B1
SRSF2
U2AF1
ZRSR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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