Article
Selective Removal of 7KC by a Novel Atherosclerosis Therapeutic Candidate Reverts Foam Cells to a Macrophage-like Phenotype
2023-10-25
Abstract excerpt
The removal of the toxic oxidized cholesterol, 7-ketocholesterol (7KC), from cells through the administration of therapeutics has the potential to treat atherosclerosis and various other pathologies. While cholesterol is a necessary building block for homeostasis, oxidation of cholesterol can lead to the formation of toxic oxysterols involved in various pathologies, the most prominent of which is 7KC, which is for...
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Identifiers and source
- Literature Corpus work
- f5effea0-26fe-5c10-a2ca-cf4aa2086f61
- DOI
- 10.1101/2023.10.23.563623