Article
The G84E mutation in the HOXB13 gene is associated with an increased risk of prostate cancer in Poland.
The Prostate - 1 Apr 2013
Kluźniak Wojciech, Wokołorczyk Dominika, Kashyap Aniruddh, Jakubowska Anna, Gronwald Jacek, Huzarski Tomasz, Byrski Tomasz, Dębniak Tadeusz, Gołąb Adam, Gliniewicz Bartłomiej, Sikorski Andrzej, Switała Jerzy, Borkowski Tomasz, Borkowski Andrzej, Antczak Andrzej, Wojnar Lukasz, Przybyła Jacek, Sosnowski Marek, Małkiewicz Bartosz, Zdrojowy Romuald, Sikorska-Radek Paulina, Matych Józef, Wilkosz Jacek, Różański Waldemar, Kiś Jacek, Bar Krzysztof, Bryniarski Piotr, Paradysz Andrzej, Jersak Konrad, Niemirowicz Jerzy, Słupski Piotr, Jarzemski Piotr, Skrzypczyk Michał, Dobruch Jakub, Domagała Paweł, Akbari Mohammad R, Lubiński Jan, Narod Steven A, Cybulski Cezary
Abstract excerpt
BACKGROUND: The G84E mutation in the HOXB13 gene has been associated with a high lifetime risk of prostate cancer in North America (about 20-fold). The geographical and ethnic extent of this recurrent allele has not yet been determined. METHODS: We assayed for the presence of the G84E mutation in 3,515 prostate cancer patients and 2,604 controls from Poland and estimated the odds ratio for prostate cancer...
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