Article
Polymorphisms in genes related to one-carbon metabolism are not related to pancreatic cancer in PanScan and PanC4.
Cancer causes & control : CCC - 1 Mar 2013
Leenders Max, Bhattacharjee Samsiddhi, Vineis Paolo, Stevens Victoria, Bueno-de-Mesquita H Bas, Shu Xiao-Ou, Amundadottir Laufey, Gross Myron, Tobias Geoffrey S, Wactawski-Wende Jean, Arslan Alan A, Duell Eric J, Fuchs Charles S, Gallinger Steven, Hartge Patricia, Hoover Robert N, Holly Elizabeth A, Jacobs Eric J, Klein Alison P, Kooperberg Charles, LaCroix Andrea, Li Donghui, Mandelson Margaret T, Olson Sara H, Petersen Gloria, Risch Harvey A, Yu Kai, Wolpin Brian M, Zheng Wei, Agalliu Ilir, Albanes Demetrius, Boutron-Ruault Marie-Christine, Bracci Paige M, Buring Julie E, Canzian Federico, Chang Kenneth, Chanock Stephen J, Cotterchio Michelle, Gaziano J Michael, Giovanucci Edward L, Goggins Michael, Hallmans Göran, Hankinson Susan E, Hoffman-Bolton Judith A, Hunter David J, Hutchinson Amy, Jacobs Kevin B, Jenab Mazda, Khaw Kay-Tee, Kraft Peter, Krogh Vittorio, Kurtz Robert C, McWilliams Robert R, Mendelsohn Julie B, Patel Alpa V, Rabe Kari G, Riboli Elio, Tjønneland Anne, Trichopoulos Dimitrios, Virtamo Jarmo, Visvanathan Kala, Elena Joanne W, Yu Herbert, Zeleniuch-Jacquotte Anne, Stolzenberg-Solomon Rachael Z
Abstract excerpt
PURPOSE: The evidence of a relation between folate intake and one-carbon metabolism (OCM) with pancreatic cancer (PanCa) is inconsistent. In this study, the association between genes and single-nucleotide polymorphisms (SNPs) related to OCM and PanCa was assessed. METHODS: Using biochemical knowledge of the OCM pathway, we identified thirty-seven genes and 834 SNPs to examine in association with PanCa. Our study...
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