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Article

Intracellular lumen extension requires ERM-1-dependent apical membrane expansion and AQP-8-mediated flux.

Nature cell biology - 1 Feb 2013

Khan Liakot A, Zhang Hongjie, Abraham Nessy, Sun Lei, Fleming John T, Buechner Matthew, Hall David H, Gobel Verena

Abstract excerpt

Many unicellular tubes such as capillaries form lumens intracellularly, a process that is not well understood. Here we show that the cortical membrane organizer ERM-1 is required to expand the intracellular apical/lumenal membrane and its actin undercoat during single-cell Caenorhabditis elegans excretory canal morphogenesis. We characterize AQP-8, identified in an ERM-1-overexpression (ERM-1[++]) suppressor...

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Identifiers

PMID: 23334498
DOI: 10.1038/ncb2656
PMCID: PMC4091717

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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