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Article

Apicobasal domain identities of expanding tubular membranes depend on glycosphingolipid biosynthesis.

Nature cell biology - 18 Sept 2011

Zhang Hongjie, Abraham Nessy, Khan Liakot A, Hall David H, Fleming John T, Göbel Verena

Abstract excerpt

Metazoan internal organs are assembled from polarized tubular epithelia that must set aside an apical membrane domain as a lumenal surface. In a global Caenorhabditis elegans tubulogenesis screen, interference with several distinct fatty-acid-biosynthetic enzymes transformed a contiguous central intestinal lumen into multiple ectopic lumens. We show that multiple-lumen formation is caused by apicobasal polarity...

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Identifiers

PMID: 21926990
DOI: 10.1038/ncb2328
PMCID: PMC3249144

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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