Article
UNC93B1 and nucleic acid-sensing Toll-like receptors mediate host resistance to infection with Leishmania major.
The Journal of biological chemistry - 8 Mar 2013
Schamber-Reis Bruno Luiz Fonseca, Petritus Patricia M, Caetano Braulia C, Martinez Espiridion R, Okuda Kendi, Golenbock Douglas, Scott Phillip, Gazzinelli Ricardo T
Abstract excerpt
The mammalian homolog B1 of Unc-93 Caenorhabditis elegans known as UNC93B1 is a chaperone protein that mediates translocation of the nucleic acid-sensing Toll-like receptors (TLRs) from the endoplasmic reticulum to the endolysosomes. The triple deficient (UNC93B1 mutant) mice have a functional single point mutation in the UNC93B1 that results in non-functional TLR3, TLR7, and TLR9. Herein, we demonstrate that...
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