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Article

Distinct Bomanins at the Drosophila 55C locus function in resistance and resilience to infections.

EMBO reports - 1 Feb 2026

Lou Yanyan, Zhang Bo, Zhang Zhiyuan, Pan Yingyi, Yang Jianwen, Li Lu, Huang Jianqiong, Yuan Zihang, Liegeois Samuel, Bulet Philippe, Xu Rui, Zi Li, Ferrandon Dominique

Abstract excerpt

Host defense against many Gram-positive bacteria and fungal pathogens is mainly provided by the Toll-dependent systemic immune response in Drosophila. While antimicrobial peptides active against these categories of pathogens contribute only modestly to protection, Bomanin peptides are major effectors of the Toll pathway. Remarkably, flies deleted for the 55C locus that contains ten Bomanin genes are as sensitive...

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Identifiers

PMID: 41513836
DOI: 10.1038/s44319-025-00559-6
PMCID: PMC12894722

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