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Article

The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9.

Nature immunology - 1 Feb 2006

Tabeta Koichi, Hoebe Kasper, Janssen Edith M, Du Xin, Georgel Philippe, Crozat Karine, Mudd Suzanne, Mann Navjiwan, Sovath Sosathya, Goode Jason, Shamel Louis, Herskovits Anat A, Portnoy Daniel A, Cooke Michael, Tarantino Lisa M, Wiltshire Tim, Steinberg Benjamin E, Grinstein Sergio, Beutler Bruce

Abstract excerpt

Here we have identified 'triple D' (3d), a recessive N-ethyl-N-nitrosourea-induced mutation and phenotype in which no signaling occurs via the intracellular Toll-like receptors 3, 7 and 9 (sensors for double-stranded RNA, single-stranded RNA and unmethylated DNA, respectively). The 3d mutation al...

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Identifiers

PMID: 16415873
DOI: 10.1038/ni1297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16415873-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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