Article
Ethanol-induced mast cell-mediated inflammation leads to increased susceptibility of intestinal tumorigenesis in the APC Δ468 min mouse model of colon cancer.
Alcoholism, clinical and experimental research - 1 Jan 2013
Wimberly Andre L, Forsyth Christopher B, Khan Mohammad W, Pemberton Alan, Khazaie Khashayarsha, Keshavarzian Ali
Abstract excerpt
BACKGROUND: Chronic and frequent alcohol (ethanol [EtOH]) intake has been associated with an increased incidence of several types of cancers including breast, mouth, throat, esophageal, stomach, and colorectal (CRC). The underlying mechanism of this deleterious carcinogenic effect of alcohol has not been clearly established but inflammation may be 1 unifying feature of these cancers. We have recently shown that...
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