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Article

Distinct Small Intestine Mast Cell Histologic Changes in Patients With Hereditary Alpha-tryptasemia and Mast Cell Activation Syndrome.

The American journal of surgical pathology - 1 Jul 2021

Hamilton Matthew J, Zhao Melissa, Giannetti Matthew P, Weller Emily, Hufdhi Raied, Novak Peter, Mendoza-Alvarez Lybil B, Hornick Jason, Lyons Jonathan J, Glover Sarah C, Castells Mariana C, Pozdnyakova Olga

Abstract excerpt

Mast cells (MCs) are important in intestinal homeostasis and pathogen defense but are also implicated in many of the clinical manifestations in disorders such as irritable bowel syndrome. The utility of specific staining for MCs to quantify and phenotype them in intestinal biopsies in patients with gastrointestinal (GI) symptoms is controversial and is not a widely adopted practice. Whether or not intestinal MCs...

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Identifiers

PMID: 33481382
DOI: 10.1097/PAS.0000000000001676
PMCID: PMC8192345

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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