Article
MMP12 knockout prevents weight and muscle loss in tumor-bearing mice.
BMC cancer - 4 Dec 2021
Jiang Lingbi, Yang Mingming, He Shihui, Li Zhengyang, Li Haobin, Niu Ting, Xie Dehuan, Mei Yan, He Xiaodong, Wei Lili, Huang Pinzhu, Huang Mingzhe, Zhang Rongxin, Wang Lijing, Li Jiangchao
Abstract excerpt
BACKGROUND: Colorectal cancer is a malignant gastrointestinal cancer, in which some advanced patients would develop cancer cachexia (CAC). CAC is defined as a multi-factorial syndrome characterized by weight loss and muscle loss (with or without fat mass), leading to progressive dysfunction, thereby increasing morbidity and mortality. ApcMin/+ mice develop spontaneous intestinal adenoma, which provides an...
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