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Article

Adaptive evolution of the Streptococcus pyogenes regulatory aldolase LacD.1.

Journal of bacteriology - 1 Mar 2013

Cusumano Zachary, Caparon Michael

Abstract excerpt

In the human-pathogenic bacterium Streptococcus pyogenes, the tagatose bisphosphate aldolase LacD.1 likely originated through a gene duplication event and was adapted to a role as a metabolic sensor for regulation of virulence gene transcription. Although LacD.1 retains enzymatic activity, its an...

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Identifiers

PMID: 23316044
DOI: 10.1128/JB.01997-12
PMCID: PMC3592009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23316044-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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