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Article

A compromise required by gene sharing enables survival: Implications for evolution of new enzyme activities.

Proceedings of the National Academy of Sciences of the United States of America - 9 Sept 2008

McLoughlin Sean Yu, Copley Shelley D

Abstract excerpt

Evolution of new enzymatic activities is believed to require a period of gene sharing in which a single enzyme must serve both its original function and a new function that has become advantageous to the organism. Subsequent gene duplication allows one copy to maintain the original function, while the other diverges to optimize the new function. The physiological impact of gene sharing and the constraints imposed...

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Share to Aldehyde Oxidoreductases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18757760
DOI: 10.1073/pnas.0804804105
PMCID: PMC2533218

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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