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Article

Bacilli glutamate dehydrogenases diverged via coevolution of transcription and enzyme regulation.

EMBO reports - 1 Jul 2017

Noda-Garcia Lianet, Romero Romero Maria Luisa, Longo Liam M, Kolodkin-Gal Ilana, Tawfik Dan S

Abstract excerpt

The linkage between regulatory elements of transcription, such as promoters, and their protein products is central to gene function. Promoter-protein coevolution is therefore expected, but rarely observed, and the manner by which these two regulatory levels are linked remains largely unknown. We study glutamate dehydrogenase-a hub of carbon and nitrogen metabolism. In Bacillus subtilis, two paralogues exist: GudB...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28468957
DOI: 10.15252/embr.201743990
PMCID: PMC5494520

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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