Case-control inference of interaction between genetic and nongenetic risk factors under assumptions on their distribution.

Abstract excerpt

In genetic association studies, there is increasing interest in understanding the joint effects of genetic and nongenetic factors. For rare diseases, the case-control study is a practical design, and logistic regression is the standard method of inference. However, the power to detect statistical interaction is a concern, even with relatively large samples. Under independence of genetic and nongenetic covariates,...

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