A novel Bayesian semiparametric algorithm for inferring population structure and adjusting for case-control association tests.

Abstract excerpt

While the population-based case-control approach is the popular study design for association mapping of complex genetic traits because of ease of data collection and statistical analyses, it suffers from the inherent problem of population stratification. There have been methodological developments for adjusting these studies for population substructure, but efficient estimation of the number of subpopulations...

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