Article
Candidate gene studies of a promising intermediate phenotype: failure to replicate.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Apr 2013
Hart Amy B, de Wit Harriet, Palmer Abraham A
Abstract excerpt
Many candidate gene studies use 'intermediate phenotypes' instead of disease diagnoses. It has been proposed that intermediate phenotypes have simpler genetic architectures such that individual alleles account for a larger percentage of trait variance. This implies that smaller samples can be used to identify genetic associations. Pharmacogenomic drug challenge studies may be an especially promising class of...
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