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Article

SOX4 mediates TGF-β-induced expression of mesenchymal markers during mammary cell epithelial to mesenchymal transition.

PloS one - 1 Jan 2013

Vervoort Stephin J, Lourenço Ana Rita, van Boxtel Ruben, Coffer Paul J

Abstract excerpt

The epithelial to mensenchymal transition program regulates various aspects of embryonic development and tissue homeostasis, but aberrant activation of this pathway in cancer contributes to tumor progression and metastasis. TGF-b potently induces an epithelial to mensenchymal transition in cancers of epithelial origin by inducing transcriptional changes mediated by several key transcription factors. Here, we...

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Identifiers

PMID: 23301048
DOI: 10.1371/journal.pone.0053238
PMCID: PMC3536747

Genes

SOX4

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