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Article

Gleevec, an Abl family inhibitor, produces a profound change in cell shape and migration.

PloS one - 1 Jan 2013

Chen Zaozao, Lessey Elizabeth, Berginski Matthew E, Cao Li, Li Jonathan, Trepat Xavier, Itano Michelle, Gomez Shawn M, Kapustina Maryna, Huang Cai, Burridge Keith, Truskey George, Jacobson Ken

Abstract excerpt

The issue of how contractility and adhesion are related to cell shape and migration pattern remains largely unresolved. In this paper we report that Gleevec (Imatinib), an Abl family kinase inhibitor, produces a profound change in the shape and migration of rat bladder tumor cells (NBTII) plated on collagen-coated substrates. Cells treated with Gleevec adopt a highly spread D-shape and migrate more rapidly with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23300967
DOI: 10.1371/journal.pone.0052233
PMCID: PMC3534684

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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