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Article

The ROCK isoforms differentially regulate the morphological characteristics of carcinoma cells.

Small GTPases - 1 Mar 2020

Jerrell Rachel J, Leih Mitchell J, Parekh Aron

Abstract excerpt

Rho-associated kinase (ROCK) activity drives cell migration via actomyosin contractility. During invasion, individual cancer cells can transition between 2 modes of migration, mesenchymal and amoeboid. Changes in ROCK activity can cause a switch between these migration phenotypes which are defined by distinct morphologies. However, recent studies have shown that the ROCK isoforms are not functionally redundant as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28650698
DOI: 10.1080/21541248.2017.1341366
PMCID: PMC7053931

Genes

ROCK1
ROCK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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