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Homozygous T172T and Heterozygous G135C Variants of Homologous Recombination Repairing Protein RAD51 are Related to Sporadic Breast Cancer Susceptibility.

Biochemical genetics - 1 Feb 2016

Al-Zoubi Mazhar Salim, Mazzanti Chiara Maria, Zavaglia Katia, Al Hamad Mohammad, Armogida Ivana, Lisanti Michael P, Bevilacqua Generoso

Abstract excerpt

Breast cancer (BC) is the most common cancer and the second leading cause of death among women worldwide. Only 10% of BC cases have been related to genetic predisposition. Rad51, a homologous recombination (HR) protein plays an important role in HR in meiosis and repairing DNA double-strand breaks. Expression of RAD51 may be a predictive biomarker in certain types of cancers. The exact mechanisms involved in the...

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PMID: 26650628
DOI: 10.1007/s10528-015-9703-z

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RAD51

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Homozygous T172T and Heterozygous G135C Variants of Homologous Recombination Repairing Protein RAD51 are Related to Sporadic Breast Cancer Susceptibility.PMID 26650628Read ↗

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