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Article

Variation in the RAD51 gene and familial breast cancer.

Breast cancer research : BCR - 1 Jan 2006

Lose Felicity, Lovelock Paul, Chenevix-Trench Georgia, Mann Graham J, Pupo Gulietta M, Spurdle Amanda B

Abstract excerpt

INTRODUCTION: Human RAD51 is a homologue of the Escherichia coli RecA protein and is known to function in recombinational repair of double-stranded DNA breaks. Mutations in the lower eukaryotic homologues of RAD51 result in a deficiency in the repair of double-stranded DNA breaks. Loss of RAD51 function would therefore be expected to result in an elevated mutation rate, leading to accumulation of DNA damage and,...

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Source

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Identifiers

PMID: 16762046
DOI: 10.1186/bcr1415
PMCID: PMC1557738

Genes

RAD51
BRCA1
BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Variation in the RAD51 gene and familial breast cancer.PMID 16762046Read ↗

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