Ancestral lysozymes reconstructed, neutrality tested, and thermostability linked to hydrocarbon packing.

Abstract excerpt

The controversy surrounding the idea that neutral mutations dominate protein evolution is attributable in part to the inadequacy of the tools available to evolutionary investigators. With a few exceptions, most investigations into the force driving protein evolution have relied on indirect criteria for distinguishing neutral and non-neutral variants. To investigate a particular pathway of molecular evolution, we...

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