Article
Ancestral lysozymes reconstructed, neutrality tested, and thermostability linked to hydrocarbon packing.
Nature - 3 May 1990
Malcolm B A, Wilson K P, Matthews B W, Kirsch J F, Wilson A C
Abstract excerpt
The controversy surrounding the idea that neutral mutations dominate protein evolution is attributable in part to the inadequacy of the tools available to evolutionary investigators. With a few exceptions, most investigations into the force driving protein evolution have relied on indirect criteria for distinguishing neutral and non-neutral variants. To investigate a particular pathway of molecular evolution, we...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Biological Evolution
- Birds
- Chemical Phenomena
- Chemistry, Physical
- Crystallization
- Enzyme Stability
- Genetic Variation
- Hot Temperature