Article
In vitro evolution of thermodynamically stable turns.
Nature structural biology - 1 May 1996
Zhou H X, Hoess R H, DeGrado W F
Abstract excerpt
To determine the role of primary structure in specifying turns, random sequences (guests) were substituted for the native turn sequences in a series of proteins (hosts) of differing thermodynamic stabilities.The fraction of inserts that result in active proteins is measured as a function of the s...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Base Sequence
- Biological Evolution
- Gene Library
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Structure, Secondary
- Recombinant Proteins
- Sequence Analysis, DNA
- Thermodynamics