Article
In vitro evolution of thermodynamically stable turns.
Nature structural biology - 1 May 1996
Zhou H X, Hoess R H, DeGrado W F
Abstract excerpt
To determine the role of primary structure in specifying turns, random sequences (guests) were substituted for the native turn sequences in a series of proteins (hosts) of differing thermodynamic stabilities.The fraction of inserts that result in active proteins is measured as a function of the stability of the host and temperature. With a highly stable host, more than half of the inserts give functional...
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