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Article

The role of CYP2C9 polymorphisms in phenytoin-related cerebellar atrophy.

Seizure - 1 Apr 2013

Twardowschy Carlos A, Werneck Lineu C, Scola Rosana H, Borgio João G, De Paola Luciano, Silvado Carlos

Abstract excerpt

PURPOSE: Phenytoin is known to be able to induce cerebellar atrophy in patients with epilepsy. It is also known that a CYP2C9 mutation (*2 or *3) reduces phenytoin metabolism by 25-50% and can increase the risk of phenytoin-related side effects. We examined the influence of CYP2C9 polymorphisms on total cerebellar volume and cerebellar gray and white matter volumes in patients with epilepsy taking phenytoin....

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Source

Identifiers

PMID: 23298603
DOI: 10.1016/j.seizure.2012.12.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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