Article
A resequence analysis of genomic loci on chromosomes 1q32.1, 5p15.33, and 13q22.1 associated with pancreatic cancer risk.
Pancreas - 1 Mar 2013
Parikh Hemang, Jia Jinping, Zhang Xijun, Chung Charles C, Jacobs Kevin B, Yeager Meredith, Boland Joseph, Hutchinson Amy, Burdett Laura, Hoskins Jason, Risch Harvey A, Stolzenberg-Solomon Rachael Z, Chanock Stephen J, Wolpin Brian M, Petersen Gloria M, Fuchs Charles S, Hartge Patricia, Amundadottir Laufey
Abstract excerpt
OBJECTIVE: The objective of this study was to fine-map common pancreatic cancer susceptibility regions. METHODS: We conducted targeted Roche-454 resequencing across 428 kb in 3 genomic regions identified in genome-wide association studies (GWAS) of pancreatic cancer, on chromosomes 1q32.1, 5p15.33, and 13q22.1. RESULTS: An analytical pipeline for calling genotypes was developed using HapMap samples sequenced on...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
