Identification of Pancreatic Cancer Germline Risk Variants With Effects That Are Modified by Smoking.

Abstract excerpt

PURPOSE: Pancreatic cancer (PC) is a deadly disease most often diagnosed in late stages. Identification of high-risk subjects could both contribute to preventative measures and help diagnose the disease at earlier timepoints. However, known risk factors, assessed independently, are currently insufficient for accurately stratifying patients. We use large-scale data from the UK Biobank (UKB) to identify genetic...

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• PC gene
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Germ Cells
• Pancreatic Neoplasms