Article
Identification of Pancreatic Cancer Germline Risk Variants With Effects That Are Modified by Smoking.
JCO precision oncology - 1 Mar 2024
Zhu Huili, Choi Jaihee, Kui Naishu, Yang Tianzhong, Wei Peng, Li Donghui, Sun Ryan
Abstract excerpt
PURPOSE: Pancreatic cancer (PC) is a deadly disease most often diagnosed in late stages. Identification of high-risk subjects could both contribute to preventative measures and help diagnose the disease at earlier timepoints. However, known risk factors, assessed independently, are currently insufficient for accurately stratifying patients. We use large-scale data from the UK Biobank (UKB) to identify genetic...
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