Article
Correlation between cognitive deficits and Abeta deposits in transgenic APP+PS1 mice.
Neurobiology of aging - 1 Jan 2000
Gordon M N, King D L, Diamond D M, Jantzen P T, Boyett K V, Hope C E, Hatcher J M, DiCarlo G, Gottschall W P, Morgan D, Arendash G W
Abstract excerpt
Doubly transgenic mAPP+mPS1 mice (15-16 months) had impaired cognitive function in a spatial learning and memory task that combined features of a water maze and a radial arm maze. Nontransgenic mice learned a new platform location each day during 4 consecutive acquisition trials, and exhibited memory for this location in a retention trial administered 30 min later. In contrast, transgenic mice were, on average,...
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