Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Age-related cognitive decline and nesting behavior in an APPswe/PS1 bigenic model of Alzheimer's disease.

Brain research - 6 Oct 2009

Filali Mohammed, Lalonde Robert

Abstract excerpt

A large series of 3-, 6-, 9-, and 12-month-old bigenic mice (N=240) with Swedish APP and A246E PS1 mutations was investigated in nest-building, spontaneous alternation, and two learning tasks. Progressive cognitive impairment was observed in APPswe/PS1 mice relative to controls for nest-building,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Protein Precursor
Share to Avoidance Learning
Share to Cognition Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Discrimination Learning

Share to Learning Disabilities

Share to Maze Learning

Share to Nesting Behavior

Share to Presenilin-1

Source

Identifiers

PMID: 19643098
DOI: 10.1016/j.brainres.2009.07.066

Genes

APP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19643098-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Age-related cognitive decline and nesting behavior in an APPswe/PS1 bigenic model of Alzheimer's disease.PMID 19643098Read ↗

Behavioral abnormalities in APPSwe/PS1dE9 mouse model of AD-like pathology: comparative analysis across multiple behavioral domains.Semantic proximity Read ↗

Effects of accelerated senescence on learning and memory, locomotion and anxiety-like behavior in APP/PS1 mouse model of Alzheimer's disease.Semantic proximity Read ↗

Longitudinal behavioral changes in the APP/PS1 transgenic Alzheimer's disease model.Semantic proximity Read ↗

Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes.Semantic proximity Read ↗

Motor activity in young APPswe + PS1/A246E bigenic mice as a predicting variable for memory decline.Semantic proximity Read ↗

Hippocampal spatial memory impairments caused by the familial Alzheimer's disease-linked presenilin 1 M146V mutation.Semantic proximity Read ↗

Age-dependent phenotypic characteristics of a triple transgenic mouse model of Alzheimer disease.Semantic proximity Read ↗

Locomotor activity, emotionality, sensori-motor gating, learning and memory in the APPswe/PS1dE9 mouse model of Alzheimer's disease.Semantic proximity Read ↗

Histological and Behavioral Phenotypes of a Novel Mutated APP Knock-In Mouse.Semantic proximity Read ↗

Transgenic mice expressing the PS1-A246E mutation: effects on spatial learning, exploration, anxiety, and motor coordination.Semantic proximity Read ↗

APP transgenic mice for modelling behavioural and psychological symptoms of dementia (BPSD).Semantic proximity Read ↗

Early-in-life neuroanatomical and behavioural trajectories in a triple transgenic model of Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.