Article
Mice lacking the beta3 subunit of the GABAA receptor have the epilepsy phenotype and many of the behavioral characteristics of Angelman syndrome.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Oct 1998
DeLorey T M, Handforth A, Anagnostaras S G, Homanics G E, Minassian B A, Asatourian A, Fanselow M S, Delgado-Escueta A, Ellison G D, Olsen R W
Abstract excerpt
Angelman syndrome (AS) is a severe neurodevelopmental disorder resulting from a deletion/mutation in maternal chromosome 15q11-13. The genes in 15q11-13 contributing to the full array of the clinical phenotype are not fully identified. This study examines whether a loss or reduction in the GABAA...
Topics
- Age Factors
- Angelman Syndrome
- Animals
- Avoidance Learning
- Behavior, Animal
- Chromosome Mapping
- Chromosomes, Human, Pair 15
- Conditioning, Psychological
- Disease Models, Animal
- Electroencephalography
- Epilepsy
- Fear
- Genotype