Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification and characterization of xiamycin A and oxiamycin gene cluster reveals an oxidative cyclization strategy tailoring indolosesquiterpene biosynthesis.

Journal of the American Chemical Society - 30 May 2012

Li Huixian, Zhang Qingbo, Li Sumei, Zhu Yiguang, Zhang Guangtao, Zhang Haibo, Tian Xinpeng, Zhang Si, Ju Jianhua, Zhang Changsheng

Abstract excerpt

Xiamycin A (XMA) and oxiamycin (OXM) are bacterial indolosesquiterpenes featuring rare pentacyclic ring systems and are isolated from a marine-derived Streptomyces sp. SCSIO 02999. The putative biosynthetic gene cluster for XMA/OXM was identified by a partial genome sequencing approach. Eighteen genes were proposed to be involved in XMA/OXM biosynthesis, including five genes for terpene synthesis via a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biocatalysis
Share to Carrier Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclization

Share to Gene Expression Regulation, Bacterial

Share to Multigene Family

Share to Oxidation-Reduction

Share to Sesquiterpenes

Share to Streptomyces

Source

Identifiers

PMID: 22591327
DOI: 10.1021/ja303004g

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification and characterization of xiamycin A and oxiamycin gene cluster reveals an oxidative cyclization strategy tailoring indolosesquiterpene biosynthesis.PMID 22591327Read ↗

A family of multicyclic indolosesquiterpenes from a bacterial endophyteSemantic proximity Read ↗

Characterization of the biosynthetic gene cluster of the polyene macrolide antibiotic reedsmycins from a marine-derived Streptomyces strainSemantic proximity Read ↗

OSMAC-Based Discovery and Biosynthetic Gene Clusters Analysis of Secondary Metabolites from Marine-Derived Streptomyces globisporus SCSIO LCY30Semantic proximity Read ↗

Sattahipmycin, a Hexacyclic Xanthone Produced by a Marine-Derived StreptomycesSemantic proximity Read ↗

Biosynthesis of antibiotic chuangxinmycin from Actinoplanes tsinanensisSemantic proximity Read ↗

Huanglongmycin A-C, Cytotoxic Polyketides Biosynthesized by a Putative Type II Polyketide Synthase From Streptomyces sp. CB09001Semantic proximity Read ↗

Identification and Proposed Relative and Absolute Configurations of Niphimycins C–E from the Marine-Derived Streptomyces sp. IMB7-145 by Genomic AnalysisSemantic proximity Read ↗

Bacterial Biosynthetic Gene Clusters Encoding the Anti-cancer Haterumalide Class of MoleculesSemantic proximity Read ↗

Enfumafungin synthase represents a novel lineage of fungal triterpene cyclasesSemantic proximity Read ↗

Two of a Kind--The Biosynthetic Pathways of Chlorotonil and Anthracimycin.Semantic proximity Read ↗

Sesterterpene ophiobolin biosynthesis involving multiple gene clusters in Aspergillus ustus.Semantic proximity Read ↗

In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assemblySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.