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Article

Reproduction and immunity-driven natural selection in the human WFDC locus.

Molecular biology and evolution - 1 Apr 2013

Ferreira Zélia, Seixas Susana, Andrés Aida M, Kretzschmar Warren W, Mullikin James C, Cherukuri Praveen F, Cruz Pedro, Swanson Willie J, Clark Andrew G, Green Eric D, Hurle Belen

Abstract excerpt

The whey acidic protein (WAP) four-disulfide core domain (WFDC) locus located on human chromosome 20q13 spans 19 genes with WAP and/or Kunitz domains. These genes participate in antimicrobial, immune, and tissue homoeostasis activities. Neighboring SEMG genes encode seminal proteins Semenogelin 1 and 2 (SEMG1 and SEMG2). WFDC and SEMG genes have a strikingly high rate of amino acid replacement (dN/dS), indicative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23292442
DOI: 10.1093/molbev/mss329
PMCID: PMC3603315

Genes

SEMG1
SEMG2
SLPI
WFDC8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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