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Article

Comparative sequence analyses reveal rapid and divergent evolutionary changes of the WFDC locus in the primate lineage.

Genome research - 1 Mar 2007

Hurle Belen, Swanson Willie, Green Eric D

Abstract excerpt

The initial comparison of the human and chimpanzee genome sequences revealed 16 genomic regions with an unusually high density of rapidly evolving genes. One such region is the whey acidic protein (WAP) four-disulfide core domain locus (or WFDC locus), which contains 14 WFDC genes organized in two subloci on human chromosome 20q13. WAP protease inhibitors have roles in innate immunity and/or the regulation of a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17267810
DOI: 10.1101/gr.6004607
PMCID: PMC1800918

Genes

SEMG2
SEMG1
MATN4
SLPI
WFDC12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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