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Article

Sequence variation at KLK and WFDC clusters and its association to semen hyperviscosity and other male infertility phenotypes.

Human reproduction (Oxford, England) - 1 Dec 2016

Marques Patrícia Isabel, Fonseca Filipa, Carvalho Ana Sofia, Puente Diana A, Damião Isabel, Almeida Vasco, Barros Nuno, Barros Alberto, Carvalho Filipa, Azkargorta Mikel, Elortza Felix, Osório Hugo, Matthiesen Rune, Quesada Victor, Seixas Susana

Abstract excerpt

STUDY QUESTION: Are kallikreins (KLKs), the whey-acidic-protein four-disulfide core domain (WFDCs) and their neighbors, semenogelins (SEMGs), known to play a role in the cascade of semen coagulation and liquefaction, associated with male infertility? SUMMARY ANSWER: Several KLK and SEMG variants are overrepresented among hyperviscosity, asthenozoospermia and oligozoospermia, supporting an effect of abnormal semen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27827323
DOI: 10.1093/humrep/dew267

Genes

EPPIN
KLK3
KLK7
SEMG1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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